Mapping Social Behavior-Induced Brain Activation at Cellular Resolution in the Mouse
Name
Kim-2015-Mapping social behav.pdf
Size
4.15 MB
Format
Adobe PDF
Checksum (MD5)
44ecb772bf30bcbd9854e5ed0ecca137
Author(s)
Kim, Yongsoo
Venkataraju, Kannan Umadevi
Pradhan, Kith
Mende, Carolin
Taranda, Julian
Turaga, Srinivas C.
Arganda-Carreras, Ignacio
Ng, Lydia
Hawrylycz, Michael J.
Rockland, Kathleen S.
Date Issued
December 2014
Journal
Cell Reports
Publisher
Elsevier
Citation
Kim, Yongsoo, Kannan Umadevi Venkataraju, Kith Pradhan, Carolin Mende, Julian Taranda, Srinivas C. Turaga, Ignacio Arganda-Carreras, et al. “Mapping Social Behavior-Induced Brain Activation at Cellular Resolution in the Mouse.” Cell Reports 10, no. 2 (January 2015): 292–305.
Version
Final published version
Abstract
Understanding how brain activation mediates behaviors is a central goal of systems neuroscience. Here, we apply an automated method for mapping brain activation in the mouse in order to probe how sex-specific social behaviors are represented in the male brain. Our method uses the immediate-early-gene c-fos, a marker of neuronal activation, visualized by serial two-photon tomography: the c-fos-GFP+ neurons are computationally detected, their distribution is registered to a reference brain and a brain atlas, and their numbers are analyzed by statistical tests. Our results reveal distinct and shared female and male interaction-evoked patterns of male brain activation representing sex discrimination and social recognition. We also identify brain regions whose degree of activity correlates to specific features of social behaviors and estimate the total numbers and the densities of activated neurons per brain areas. Our study opens the door to automated screening of behavior-evoked brain activation in the mouse.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.celrep.2014.12.014
