Global Analysis of Macular Choriocapillaris Perfusion in Dry Age-Related Macular Degeneration using Swept-Source Optical Coherence Tomography Angiography
Name
i1552-5783-60-15-4985.pdf
Description
Published version
Size
1.04 MB
Format
Adobe PDF
Checksum (MD5)
ae39ab6d0ffc25fc3372652e49f7e719
Author(s)
Braun, Phillip X.
Mehta, Nihaal
Gendelman, Isaac
Alibhai, A. Yasin
Moult, Eric Michael
Zhao, Yi
Ishibazawa, Akihiro
Sorour, Osama
Konstantinou, Eleni K.
Baumal, Caroline R.
Date Issued
December 2019
Journal
Investigative Ophthalmology and Visual Science
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Citation
Braun, Phillip X. et al. "Global Analysis of Macular Choriocapillaris Perfusion in Dry Age-Related Macular Degeneration using Swept-Source Optical Coherence Tomography Angiography." Investigative Ophthalmology and Visual Science 60, 15 (December 2019): 4985–4990. © 2019 The Authors
Version
Final published version
Abstract
PURPOSE: Swept-source optical coherence tomography angiography (SS-OCTA) was used to investigate if the clinical stage of dry age-related macular degeneration (AMD) was correlated with global and regional macular choriocapillaris (CC) perfusion. METHODS: In this retrospective, cross-sectional study, 6 3 6-mm SS-OCTA images from eyes with early, intermediate, and advanced dry AMD (56 eyes, 41 patients) were analyzed using algorithms described in the literature to assess regional flow deficit percentage (FD%) and average flow deficit size. Regions were defined by concentric areas centered on the fovea: a 1-mm-diameter area, 3-mm-diameter ring, 5-mm-diameter area, 5-mm-diameter ring, and 6 3 6-mm whole image. Data were modeled using the generalized estimating equations approach. RESULTS: The relationship between age and CC FD% and average flow deficit size was statistically significant (P ≼ 0.05) in all regions of analysis by linear modeling. The relationship between dry AMD stage and FD% was statistically significant by linear modeling in the 5-mm ring, and between dry AMD stage and average flow deficit size in the 3-mm ring, 5-mm area, 5-mm ring, and 6 3 6-mm whole image. CONCLUSIONS. Linear modeling suggests a statistically significant relationship between dry AMD stage and CC perfusion, most prominent in the more peripheral regions of the macula.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1167/iovs.19-27861
