New immobilized antimicrobial polyethylenimines : synthesis and properties
Name
899244071-MIT.pdf
Description
Full printable version
Size
7.49 MB
Format
Adobe PDF
Checksum (MD5)
55fd78a13c455361b3e2157fd969a82e
Author(s)
Liu, Harris K. (Harris Ken-Ming)
Advisor(s)
Alexander M. Klibanov.
Date Issued
2014
Publisher
Massachusetts Institute of Technology
Abstract
Surfaces modified with immobilized N-alkyl-polyethylenimines (N-alkyl-PEls) containing various alkyl groups were synthesized and tested against various pathogenic human influenza viruses to establish structure-to-virucidal activity relationships. Various physical-chemical properties of each surface were correlated with their virucidal activities to identify key antiviral surface properties. The accessibility of N-alkyl-PEI quaternary ammonium groups to influenza virus was subsequently identified as the key determinant of antiviral efficacy, as demonstrated by FITC-lysozyme surface titration. Previously used multistep syntheses to create antimicrobial surfaces by immobilizing Nalkyl- PEls were replaced with a novel aerosol-assisted plasma deposition procedure. N,N-hexyl,methyl-polyethylenimines were directly plasma-coated onto a glass surface. The resulting material was thoroughly characterized and demonstrated to be robust, scalable, bactericidal against Escherichia cofi, and virucidal against human influenza virus. Biocompatibility and bactericidal properties of N-alkyl-PEls immobilized on Boston Keratoprosthetic implants were evaluated in vivo. Surface-attached N,N-hexyl,methylpolyethylenimines exhibited inhibitory effects on Staphylococcus aureus biofilm formation, with no toxicity or adverse reactivity detected.
Description
Thesis: S.M., Massachusetts Institute of Technology, Department of Chemistry, 2014.
Cataloged from PDF version of thesis.
Includes bibliographical references.
Subjects
Chemistry.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Terms of Use
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