Design and Synthesis of a Novel Triptycene-Based Ligand for Modeling Carboxylate-Bridged Diiron Enzyme Active Sites
Name
Lippard_Design and synthesis.pdf
Size
585.2 KB
Format
Adobe PDF
Checksum (MD5)
59dde9b1b3c5f851ab3cd464ab309a0e
Author(s)
Li, Yang
Cao, Rui
Lippard, Stephen J.
Date Issued
August 2011
Journal
Organic Letters
Publisher
American Chemical Society (ACS)
Citation
Li, Yang, Rui Cao, and Stephen J. Lippard. “Design and Synthesis of a Novel Triptycene-Based Ligand for Modeling Carboxylate-Bridged Diiron Enzyme Active Sites.” Organic Letters 13, no. 19 (October 7, 2011): 5052-5055.
Version
Author's final manuscript
Abstract
A novel triptycene-based ligand with a preorganized framework was designed to model carboxylate-bridged diiron active sites in bacterial multicomponent monooxygenase (BMM) hydroxylase enzymes. The synthesis of the bis(benzoxazole)-appended ligand L1 depicted was accomplished in 11 steps. Reaction of L1 with iron(II) triflate and a carboxylate source afforded the desired diiron(II) complex [Fe[subscript 2]L1(μ-OH)(μ-O[subscript 2]CAr[superscript Tol])(OTf)[subscript 2]].
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1021/ol201882v
