Metastatic Cells Will Take Any Help They Can Get
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Hynes_Metastatic cells.pdf
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60.57 KB
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Adobe PDF
Checksum (MD5)
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Author(s)
Hynes, Richard O
Date Issued
December 2011
Journal
Cancer Cell
Publisher
Elsevier
Citation
Hynes, Richard O. “Metastatic Cells Will Take Any Help They Can Get.” Cancer Cell 20, no. 6 (December 2011): 689-690. Copyright © 2011 Elsevier Inc.
Version
Final published version
Abstract
Two recent papers in Cancer Cell (Lu et al., this issue of Cancer Cell, and Kang et al.) illustrate means whereby acquisition of VCAM-1 by tumor cells can promote metastasis. First, monocyte/macrophages expressing α4 integrin bind VCAM-1 and provide survival signals enhancing establishment of metastases. Second, VCAM-1 allows dormant tumor cells to interact with osteoclasts, yielding paracrine signals and enhancing osteolytic metastatic growth.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1016/j.ccr.2011.11.022
