Processes for design, construction and utilisation of arrays of light-emitting diodes and light-emitting diode-coupled optical fibres for multi-site brain light delivery
Name
Boyden_Processes for design.pdf
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502.03 KB
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Adobe PDF
Checksum (MD5)
8fe03b93b72412b838b5b51237cdd693
Author(s)
Bernstein, Jacob G.
Allen, Brian Douglas
Guerra, Alexander A.
Boyden, Edward Stuart
Date Issued
May 2015
Journal
Journal of Engineering
Publisher
Institution of Engineering and Technology (IET)
Citation
Bernstein, Jacob Gold, Brian Douglas Allen, Alexander A. Guerra, and Edward Stuart Boyden. "Processes for design, construction and utilisation of arrays of light-emitting diodes and light-emitting diode-coupled optical fibres for multi-site brain light delivery." Journal of Engineering, 2015, 8 pp.
Version
Final published version
Abstract
Optogenetics enables light to be used to control the activity of genetically targeted cells in the living brain. Optical fibres can be used to deliver light to deep targets, and light-emitting diodes (LEDs) can be spatially arranged to enable patterned light delivery. In combination, arrays of LED-coupled optical fibres can enable patterned light delivery to deep targets in the brain. Here the authors describe the process flow for making LED arrays and LED-coupled optical fibre arrays, explaining key optical, electrical, thermal and mechanical design principles to enable the manufacturing, assembly and testing of such multi-site targetable optical devices. They also explore accessory strategies such as surgical automation approaches as well as innovations to enable low-noise concurrent electrophysiology.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Massachusetts Institute of Technology. Media Laboratory
McGovern Institute for Brain Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1049/joe.2014.0304
