Adaptive Biomedical Innovation: Evolving Our Global System to Sustainably and Safely Bring New Medicines to Patients in Need
Name
Hirsch_et_al-2016-Clinical_Pharmacology_%26_Therapeutics.pdf
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2.46 MB
Format
Adobe PDF
Checksum (MD5)
513096c58b51c92456a40ff91aefd087
Author(s)
Cobbs, E
Bala, M
Hartman, D
Lumpkin, M
Lim, R
Pezalla, E
Saltonstall, P
Trusheim, Mark
Garner, Steven K.
Isaacs, Kate W.
Date Issued
September 2016
Journal
Clinical Pharmacology & Therapeutics
Publisher
Wiley
Citation
Hirsch, G, M Trusheim, E Cobbs, M Bala, S Garner, D Hartman, K Isaacs, et al. “Adaptive Biomedical Innovation: Evolving Our Global System to Sustainably and Safely Bring New Medicines to Patients in Need.” Clinical Pharmacology & Therapeutics 100, no. 6 (October 22, 2016): 685–698.
Version
Final published version
Abstract
The current system of biomedical innovation is unable to keep pace with scientific advancements. We propose to address this gap by reengineering innovation processes to accelerate reliable delivery of products that address unmet medical needs. Adaptive biomedical innovation (ABI) provides an integrative, strategic approach for process innovation. Although the term “ABI” is new, it encompasses fragmented “tools” that have been developed across the global pharmaceutical industry, and could accelerate the evolution of the system through more coordinated application. ABI involves bringing stakeholders together to set shared objectives, foster trust, structure decision-making, and manage expectations through rapid-cycle feedback loops that maximize product knowledge and reduce uncertainty in a continuous, adaptive, and sustainable learning healthcare system. Adaptive decision-making, a core element of ABI, provides a framework for structuring decision-making designed to manage two types of uncertainty – the maturity of scientific and clinical knowledge, and the behaviors of other critical stakeholders.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Massachusetts Institute of Technology. Center for Biomedical Innovation
Sloan School of Management
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1002/CPT.509
