Low-Transition-Temperature Mixtures (LTTMs) for Dissolving Proteins and for Drug Formulation
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Author(s)
Su, Erzheng
Klibanov, Alexander M.
Date Issued
August 2015
Journal
Applied Biochemistry and Biotechnology
Publisher
Springer US
Citation
Su, Erzheng, and Alexander M. Klibanov. “Low-Transition-Temperature Mixtures (LTTMs) for Dissolving Proteins and for Drug Formulation.” Applied Biochemistry and Biotechnology 177, no. 3 (August 4, 2015): 753–758.
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Author's final manuscript
Abstract
Several diverse proteins are found to readily dissolve in neat low-transition-temperature mixtures (LTTMs). They undergo no irreversible denaturation in such unusual solvents, and the resistance of hen egg-white lysozyme against thermoinactivation in LTTMs is greater than in aqueous solution at extreme pHs. Separately, the water-sensitive drug aspirin is found to form concentrated transparent LTTMs, where it is some 10-fold more stable against cleavage than in water.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Chemistry
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1007/s12010-015-1777-x
