Broadband slow-wave modulation in posterior and anterior cortex tracks distinct states of propofol-induced unconsciousness
Name
s41598-020-68756-y.pdf
Description
Published version
Size
1.73 MB
Format
Adobe PDF
Checksum (MD5)
962f236f7a08d444586fe875ac86e997
Author(s)
Stephen, Emily P
Hotan, Gladia C
Pierce, Eric T
Harrell, P Grace
Walsh, John L
Brown, Emery Neal
Purdon, Patrick L
Date Issued
2020
Journal
Scientific Reports
Publisher
Springer Science and Business Media LLC
Version
Final published version
Abstract
© 2020, The Author(s). A controversy has developed in recent years over the roles of frontal and posterior cortices in mediating consciousness and unconsciousness. Disruption of posterior cortex during sleep appears to suppress the contents of dreaming, yet activation of frontal cortex appears necessary for perception and can reverse unconsciousness under anesthesia. We used anesthesia to study how regional cortical disruption, mediated by slow wave modulation of broadband activity, changes during unconsciousness in humans. We found that broadband slow-wave modulation enveloped posterior cortex when subjects initially became unconscious, but later encompassed both frontal and posterior cortex when subjects were more deeply anesthetized and likely unarousable. Our results suggest that unconsciousness under anesthesia comprises several distinct shifts in brain state that disrupt the contents of consciousness distinct from arousal and awareness of those contents.
MIT Department
Picower Institute for Learning and Memory
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Harvard University--MIT Division of Health Sciences and Technology
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
10.1038/S41598-020-68756-Y
https://doi.org/10.1038/S41598-020-68756-Y
