Towards More Efficient, Greener Syntheses through Flow Chemistry
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Towards More Efficient, Greener Syntheses Through Flow Chemistry.pdf
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759.18 KB
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Adobe PDF
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Author(s)
Morse, Peter D
Lummiss, Justin A.m.
Beingessner, Rachel L
Jamison, Timothy F
Date Issued
February 2017
Journal
Chemical Record, The
Publisher
Wiley Blackwell
Citation
Lummiss, Justin A.M. et al. “Towards More Efficient, Greener Syntheses through Flow Chemistry.” The Chemical Record 17, 7 (February 2017): 667–680 © 2017 Wiley-Verlag
Version
Author's final manuscript
Abstract
Technological advances have an important role in the design of greener synthetic processes. In this Personal Account, we describe a wide range of thermal, photochemical, catalytic, and biphasic chemical transformations examined by our group. Each of these demonstrate how the merits of a continuous flow synthesis platform can align with some of the goals put forth by the Twelve Principles of Green Chemistry. In particular, we illustrate the potential for improved reaction efficiency in terms of atom economy, product yield and reaction rates, the ability to design synthetic process with chemical and solvent waste reduction in mind as well as highlight the benefits of the real‐time monitoring capabilities in flow for highly controlled synthetic output.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1002/tcr.201600139
