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Sequence analysis in Bos taurus reveals pervasiveness of X–Y arms races in mammalian lineages
Name
Genome Res.-2020-Hughes-1716-26.pdf
Description
Published version
Size
2.55 MB
Format
Adobe PDF
Checksum (MD5)
139f6c7306c77baa3e0c22d2c8c2310e
Author(s)
Hughes, Jennifer F
Skaletsky, Helen
Pyntikova, Tatyana
Koutseva, Natalia
Raudsepp, Terje
Brown, Laura G
Bellott, Daniel W
Cho, Ting-Jan
Dugan-Rocha, Shannon
Khan, Ziad
Date Issued
2020
Journal
Genome Research
Publisher
Cold Spring Harbor Laboratory
Version
Final published version
Abstract
© 2020 Hughes et al. Studies of Y Chromosome evolution have focused primarily on gene decay, a consequence of suppression of crossing-over with the X Chromosome. Here, we provide evidence that suppression of X–Y crossing-over unleashed a second dynamic: selfish X–Y arms races that reshaped the sex chromosomes in mammals as different as cattle, mice, and men. Using super-resolution sequencing, we explore the Y Chromosome of Bos taurus (bull) and find it to be dominated by massive, lineage-specific amplification of testis-expressed gene families, making it the most gene-dense Y Chromosome sequenced to date. As in mice, an X-linked homolog of a bull Y-amplified gene has become testis-specific and amplified. This evolutionary convergence implies that lineage-specific X–Y coevolution through gene amplification, and the selfish forces underlying this phenomenon, were dominatingly powerful among diverse mammalian lineages. Together with Y gene decay, X–Y arms races molded mammalian sex chromosomes and influenced the course of mammalian evolution.
Terms of Use
Creative Commons Attribution NonCommercial License 4.0
Persistent DSpace Link
DOI of Published Version
10.1101/gr.269902.120
