Distinct Laminar Requirements for NMDA Receptors in Experience-Dependent Visual Cortical Plasticity
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bhz260.pdf
Description
Published version
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2.17 MB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Fong, Ming-fai
Finnie, Peter Sb
Kim, Taekeun
Thomazeau, Aurore
Kaplan, Eitan S
Cooke, Samuel F
Bear, Mark F
Date Issued
December 12, 2019
Journal
Cerebral Cortex
Publisher
Oxford University Press (OUP)
Citation
Fong, Ming-fai, Finnie, Peter Sb, Kim, Taekeun, Thomazeau, Aurore, Kaplan, Eitan S et al. 2019. "Distinct Laminar Requirements for NMDA Receptors in Experience-Dependent Visual Cortical Plasticity." Cerebral Cortex, 30 (4).
Version
Final published version
Abstract
© 2020 Oxford University Press. All rights reserved. Primary visual cortex (V1) is the locus of numerous forms of experience-dependent plasticity. Restricting visual stimulation to one eye at a time has revealed that many such forms of plasticity are eye-specific, indicating that synaptic modification occurs prior to binocular integration of thalamocortical inputs. A common feature of these forms of plasticity is the requirement for NMDA receptor (NMDAR) activation in V1.We therefore hypothesized that NMDARs in cortical layer 4 (L4), which receives the densest thalamocortical input, would be necessary for all forms of NMDAR-dependent and input-specific V1 plasticity.We tested this hypothesis in awake mice using a genetic approach to selectively delete NMDARs from L4 principal cells.We found, unexpectedly, that both stimulus-selective response potentiation and potentiation of open-eye responses following monocular deprivation (MD) persist in the absence of L4 NMDARs. In contrast, MD-driven depression of deprived-eye responses was impaired in mice lacking L4 NMDARs, as was L4 long-term depression in V1 slices. Our findings reveal a crucial requirement for L4 NMDARs in visual cortical synaptic depression, and a surprisingly negligible role for them in cortical response potentiation. These results demonstrate that NMDARs within distinct cellular subpopulations support different forms of experience-dependent plasticity.
MIT Department
Picower Institute for Learning and Memory
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
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Creative Commons Attribution NonCommercial License 4.0
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DOI of Published Version
https://doi.org/10.1093/cercor/bhz260
