Neural Correlates of Long-Term Memory Enhancement Following Retrieval Practice
Name
fnhum-15-584560.pdf
Description
Published version
Size
2.08 MB
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Unknown
Checksum (MD5)
8d798fec5bc2aeec4826b1cb4071a718
Author(s)
Marin-Garcia, Eugenia
Mattfeld, Aaron T.
Gabrieli, John D. E.
Date Issued
February 2021
Journal
Frontiers in Human Neuroscience
Publisher
Frontiers Media SA
Version
Final published version
Abstract
© Copyright © 2021 Marin-Garcia, Mattfeld and Gabrieli. Retrieval practice, relative to further study, leads to long-term memory enhancement known as the “testing effect.” The neurobiological correlates of the testing effect at retrieval, when the learning benefits of testing are expressed, have not been fully characterized. Participants learned Swahili-English word-pairs and were assigned randomly to either the Study-Group or the Test-Group. After a week delay, all participants completed a cued-recall test while undergoing functional magnetic resonance imaging (fMRI). The Test-Group had superior memory for the word-pairs compared to the Study-Group. While both groups exhibited largely overlapping activations for remembered word-pairs, following an interaction analysis the Test-Group exhibited differential performance-related effects in the left putamen and left inferior parietal cortex near the supramarginal gyrus. The same analysis showed the Study-Group exhibited greater activations in the dorsal MPFC/pre-SMA and bilateral frontal operculum for remembered vs. forgotten word-pairs, whereas the Test-Group showed the opposite pattern of activation in the same regions. Thus, retrieval practice during training establishes a unique striatal-supramarginal network at retrieval that promotes enhanced memory performance. In contrast, study alone yields poorer memory but greater activations in frontal regions.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
McGovern Institute for Brain Research at MIT
Terms of Use
Creative Commons Attribution 4.0 International license
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DOI of Published Version
https://doi.org/10.3389/fnhum.2021.584560
