A pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices
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Author(s)
Zhu, Jiahua
Nash, Landon D.
Maitland, Duncan J.
Zhang, Shiyi
Bellinger, Andrew
Glettig, Dean
Barman, Ross
Lee, Young-Ah
Cleveland, Cody
Montgomery, Veronica A.
Date Issued
July 2015
Journal
Nature Materials
Publisher
Nature Publishing Group
Citation
Zhang, Shiyi; Bellinger, Andrew M.; Glettig, Dean L.; Barman, Ross; Lee, Young-Ah Lucy; Zhu, Jiahua; Cleveland, Cody et al. “A pH-Responsive Supramolecular Polymer Gel as an Enteric Elastomer for Use in Gastric Devices.” Nature Materials 14, no. 10 (July 2015): 1065–1071 © 2014 Macmillan Publishers Limited, part of Springer Nature
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Author's final manuscript
Abstract
Devices resident in the stomach—used for a variety of clinical applications including nutritional modulation for bariatrics, ingestible electronics for diagnosis and monitoring, and gastric-retentive dosage forms for prolonged drug delivery—typically incorporate elastic polymers to compress the devices during delivery through the oesophagus and other narrow orifices in the digestive system. However, in the event of accidental device fracture or migration, the non-degradable nature of these materials risks intestinal obstruction. Here, we show that an elastic, pH-responsive supramolecular gel remains stable and elastic in the acidic environment of the stomach but can be dissolved in the neutral-pH environment of the small and large intestines. In a large animal model, prototype devices with these materials as the key component demonstrated prolonged gastric retention and safe passage. These enteric elastomers should increase the safety profile for a wide range of gastric-retentive devices.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
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DOI of Published Version
https://doi.org/10.1038/nmat4355
