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Blood-triggered generation of platinum nanoparticle functions as an anti-cancer agent
Name
s41467-019-14131-z.pdf
Description
Published version
Size
6.76 MB
Format
Adobe PDF
Checksum (MD5)
ad5cee4296626a4147ccf653703a5337
Author(s)
Zeng, Xin
Sun, Jie
Li, Suping
Shi, Jiyun
Gao, Han
Sun Leong, Wei
Wu, Yiqi
Li, Minghui
Liu, Chengxin
Li, Ping
Date Issued
2020
Journal
Nature Communications
Publisher
Springer Science and Business Media LLC
Version
Final published version
Abstract
© 2020, The Author(s). Since the discovery of metal nanoparticles (NPs) in the 1960s, unknown toxicity, cost and the ethical hurdles of research in humans have hindered the translation of these NPs to clinical use. In this work, we demonstrate that Pt NPs with protein coronas are generated in vivo in human blood when a patient is treated with cisplatin. These self-assembled Pt NPs form rapidly, accumulate in tumors, and remain in the body for an extended period of time. Additionally, the Pt NPs are safe for use in humans and can act as anti-cancer agents to inhibit chemotherapy-resistant tumor growth by consuming intracellular glutathione and activating apoptosis. The tumor inhibitory activity is greatly amplified when the Pt NPs are loaded in vitro with the chemotherapeutic drug, daunorubicin, and the formulation is effective even in daunorubicin-resistant models. These in vivo-generated metal NPs represent a biocompatible drug delivery platform for chemotherapy resistant tumor treatment.
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
10.1038/S41467-019-14131-Z
