Microbial chemical factories: recent advances in pathway engineering for synthesis of value added chemicals
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Prather_Microbial Chemical.pdf
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Author(s)
Dhamankar, Himanshu Hemant
Prather, Kristala L. Jones
Date Issued
August 2011
Journal
Current Opinion in Structural Biology
Publisher
Elsevier B.V.
Citation
Dhamankar, Himanshu, and Kristala LJ Prather 2011Microbial Chemical Factories: Recent Advances in Pathway Engineering for Synthesis of Value Added Chemicals. Current Opinion in Structural Biology 21(4): 488–494.
Version
Author's final manuscript
Abstract
The dwindling nature of petroleum and other fossil reserves has provided impetus towards microbial synthesis of fuels and value added chemicals from biomass-derived sugars as a renewable resource. Microbes have naturally evolved enzymes and pathways that can convert biomass into hundreds of unique chemical structures, a property that can be effectively exploited for their engineering into Microbial Chemical Factories (MCFs). De novo pathway engineering facilitates expansion of the repertoire of microbially synthesized compounds beyond natural products. In this review, we visit some recent successes in such novel pathway engineering and optimization, with particular emphasis on the selection and engineering of pathway enzymes and balancing of their accessory cofactors.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Synthetic Biology Center
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Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1016/j.sbi.2011.05.001
