A mouse plasma peptide atlas as a resource for disease proteomics
Name
gb-2008-9-6-r93.pdf
Size
363.86 KB
Format
Adobe PDF
Checksum (MD5)
e177e62c97579e7d9e16f5f555413666
Author(s)
Zhang, Qing
Menon, Rajasree
Wang, Hong
Bardeesy, Nabeel
Dinulescu, Daniela M.
Kucherlapati, Raju
Politi, Katerina
Aebersold, Ruedi
Deutsch, Eric W.
Pitteri, Sharon J.
Date Issued
June 2008
Journal
Genome Biology
Publisher
BioMed Central Ltd
Citation
Zhang, Qing et al. (2008). A mouse plasma peptide atlas as a resource for disease proteomics. Genome biology 9:R93/1-10.
Version
Final published version
Abstract
We present an in-depth analysis of mouse plasma leading to the development of a publicly available repository composed of 568 liquid chromatography-tandem mass spectrometry runs. A total of 13,779 distinct peptides have been identified with high confidence. The corresponding approximately 3,000 proteins are estimated to span a 7 logarithmic range of abundance in plasma. A major finding from this study is the identification of novel isoforms and transcript variants not previously predicted from genome analysis.
Subjects
Alternative splicing
Animals
Databases, protein
Humans
Mice
Peptides, analysis
Plasma, chemistry
Protein isoforms
Proteomics
Tandem mass spectrometry
MIT Department
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1186/gb-2008-9-6-r93
