A Synaptic Strategy for Consolidation of Convergent Visuotopic Maps
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Phillips-2011-A Synaptic Strategy.pdf
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Author(s)
Phillips, Marnie A.
Colonnese, Matthew T.
Goldberg, Julie
Lewis, Laura D.
Brown, Emery Neal
Constantine-Paton, Martha
Date Issued
August 2011
Journal
Neuron
Publisher
Elsevier
Citation
Phillips, Marnie A., Matthew T. Colonnese, Julie Goldberg, Laura D. Lewis, Emery N. Brown, and Martha Constantine-Paton. “A Synaptic Strategy for Consolidation of Convergent Visuotopic Maps.” Neuron 71, no. 4 (August 2011): 710–724. © 2011 Elsevier Inc.
Version
Final published version
Abstract
The mechanisms by which experience guides refinement of converging afferent pathways are poorly understood. We describe a vision-driven refinement of corticocollicular inputs that determines the consolidation of retinal and visual cortical (VC) synapses on individual neurons in the superficial superior colliculus (sSC). Highly refined corticocollicular terminals form 1–2 days after eye-opening (EO), accompanied by VC-dependent filopodia sprouting on proximal dendrites, and PSD-95 and VC-dependent quadrupling of functional synapses. Delayed EO eliminates synapses, corticocollicular terminals, and spines on VC-recipient dendrites. Awake recordings after EO show that VC and retina cooperate to activate sSC neurons, and VC light responses precede sSC responses within intervals promoting potentiation. Eyelid closure is associated with more protracted cortical visual responses, causing the majority of VC spikes to follow those of the colliculus. These data implicate spike-timing plasticity as a mechanism for cortical input survival, and support a cooperative strategy for retinal and cortical coinnervation of the sSC.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
McGovern Institute for Brain Research at MIT
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1016/j.neuron.2011.06.023
