Different gene regulation strategies revealed by analysis of binding motifs
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Mirny_Different gene regulation.pdf
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Author(s)
Mirny, Leonid A.
Wunderlich, Zeba
Date Issued
October 2009
Journal
Trends in Genetics
Publisher
Elsevier Ltd.
Citation
Wunderlich, Zeba, and Leonid A. Mirny. “Different gene regulation strategies revealed by analysis of binding motifs.” Trends in Genetics 25.10 (2009): 434-440.
Version
Author's final manuscript
Abstract
Coordinated regulation of gene expression relies on transcription factors (TFs)
binding to specific DNA sites. Our large-scale information-theoretic analysis of >950 TF-binding motifs demonstrates that prokaryotes and eukaryotes use strikingly different strategies to target TFs to specific genome locations. Although bacterial TFs can recognize a specific DNA site in the genomic background, eukaryotic TFs exhibit widespread, nonfunctional binding and require clustering of sites to achieve specificity. We find support for this mechanism in a range of experimental studies and in our evolutionary analysis of DNA-binding domains. Our systematic
characterization of binding motifs provides a quantitative assessment of the
differences in transcription regulation in prokaryotes and eukaryotes.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1016/j.tig.2009.08.003
