Nano-Layered Microneedles for Transcutaneous Delivery of Polymer Nanoparticles and Plasmid DNA
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Hammond_Nano-layed microneedles.pdf
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Author(s)
DeMuth, Peter Charles
Su, Xingfang
Samuel, Raymond E.
Hammond, Paula T
Irvine, Darrell J
Date Issued
November 2010
Journal
Advanced Materials
Publisher
Wiley-Blackwell Publishers
Citation
DeMuth, Peter C., Xingfang Su, Raymond E. Samuel, Paula T. Hammond, and Darrell J. Irvine. Nano-Layered Microneedles for Transcutaneous Delivery of Polymer Nanoparticles and Plasmid DNA. Advanced Materials 22, no. 43 (November 16, 2010): 4851-4856.
Version
Author's final manuscript
Abstract
Multilayer-coated microneedles achieve transcutaneous delivery of plasmid DNA to the viable epidermis. Cy3-labeled plasmid DNA encoding luciferase (yellow) is deposited on biodegradable microneedle arrays through multilayer self-assembly and then delivered to the skin by microneedle application to achieve colocalization with Langerhans dendritic cells (MHC II-GFP–green).
MIT Department
Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Materials Science and Engineering
Ragon Institute of MGH, MIT and Harvard
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1002/adma.201001525
