Computation of population and physiological risk parameters from cancer data
Name
53464103-MIT.pdf
Description
Full printable version
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706.47 KB
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99d5d713cb8ce2ce965c37673d133ef2
Author(s)
Hensle, David, 1981-
Advisor(s)
William G. Thilly.
Date Issued
2003
Publisher
Massachusetts Institute of Technology
Abstract
A biological hypothesis known as the "two-stage cancer model" conceptualizes carcinogenesis in mathematical terms. Prof. W. Thilly (MIT) and Prof. S. Morgenthaler (ETH,) and their students, especially Dr. Pablo Herrero-Jimenez have organized age- and birth cohort-specific cancer mortality data from the United States (1900-1997). Unfortunately, no computer program exists that permits cancer researchers to develop and explore quantitative hypotheses about the values of biological parameters through the analysis of this large and comprehensive data set. In this thesis, initial efforts of the Morgenthaler and Thilly groups have been extended by improving and transporting a preliminary Fortran program incorporating an approximate model into a Java-based program. This program, CancerFit, can be used by cancer researchers without backgrounds in mathematics or computer programming. CancerFit is the first of its kind that deals with the carcinogenic process as a whole, rather than in smaller, individual components.
Description
Thesis (M.Eng. and S.B.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2003.
Includes bibliographical references (p. 106-107).
This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Subjects
Electrical Engineering and Computer Science.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
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