Strategies to discover regulatory circuits of the mammalian immune system
Name
Regev_Strategies to discover.pdf
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1.18 MB
Format
Adobe PDF
Checksum (MD5)
92cc64e2d3dae2fe2682d8b36163e24b
Author(s)
Amit, Ido
Regev, Aviv
Hacohen, Nir
Date Issued
November 2011
Journal
Nature Reviews Immunology
Publisher
Nature Publishing Group
Citation
Amit, Ido, Aviv Regev, and Nir Hacohen. “Strategies to discover regulatory circuits of the mammalian immune system.” Nature Reviews Immunology (November 18, 2011).
Version
Author's final manuscript
Abstract
Recent advances in technologies for genome- and proteome-scale measurements and perturbations promise to accelerate discovery in every aspect of biology and medicine. Although such rapid technological progress provides a tremendous opportunity, it also demands that we learn how to use these tools effectively. One application with great potential to enhance our understanding of biological systems is the unbiased reconstruction of genetic and molecular networks. Cells of the immune system provide a particularly useful model for developing and applying such approaches. Here, we review approaches for the reconstruction of signalling and transcriptional networks, with a focus on applications in the mammalian innate immune system.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1038/nri3109
