Modular Integration of Hydrogel Neural Interfaces
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acscentsci.1c00592.pdf
Description
Published version
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10.36 MB
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Checksum (MD5)
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Author(s)
Tabet, Anthony
Antonini, Marc-Joseph
Sahasrabudhe, Atharva
Park, Jimin
Rosenfeld, Dekel
Koehler, Florian
Yuk, Hyunwoo
Hanson, Samuel
Stinson, Jordan
Stok, Melissa
Date Issued
2021
Journal
ACS Central Science
Publisher
American Chemical Society (ACS)
Citation
Tabet, Anthony, Antonini, Marc-Joseph, Sahasrabudhe, Atharva, Park, Jimin, Rosenfeld, Dekel et al. 2021. "Modular Integration of Hydrogel Neural Interfaces." ACS Central Science, 7 (9).
Version
Final published version
Abstract
Thermal drawing has been recently leveraged to yield multifunctional, fiber-based neural probes at near kilometer length scales. Despite its promise, the widespread adoption of this approach has been impeded by (1) material compatibility requirements and (2) labor-intensive interfacing of functional features to external hardware. Furthermore, in multifunctional fibers, significant volume is occupied by passive polymer cladding that so far has only served structural or electrical insulation purposes. In this article, we report a rapid, robust, and modular approach to creating multifunctional fiber-based neural interfaces using a solvent evaporation or entrapment-driven (SEED) integration process. This process brings together electrical, optical, and microfluidic modalities all encased within a copolymer comprised of water-soluble poly(ethylene glycol) tethered to water-insoluble poly(urethane) (PU-PEG). We employ these devices for simultaneous optogenetics and electrophysiology and demonstrate that multifunctional neural probes can be used to deliver cellular cargo with high viability. Upon exposure to water, PU-PEG cladding spontaneously forms a hydrogel, which in addition to enabling integration of modalities, can harbor small molecules and nanomaterials that can be released into local tissue following implantation. We also synthesized a custom nanodroplet forming block polymer and demonstrated that embedding such materials within the hydrogel cladding of our probes enables delivery of hydrophobic small molecules in vitro and in vivo. Our approach widens the chemical toolbox and expands the capabilities of multifunctional neural interfaces.
MIT Department
Massachusetts Institute of Technology. Department of Materials Science and Engineering
McGovern Institute for Brain Research at MIT
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Massachusetts Institute of Technology. Research Laboratory of Electronics
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Chemistry
Massachusetts Institute of Technology. Department of Mechanical Engineering
Massachusetts Institute of Technology. Department of Biological Engineering
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Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1021/ACSCENTSCI.1C00592
