Design of a Reconfigurable Quality Assurance Phantom for Verifying the Spatial Accuracy of Radiosurgery Treatments for Multiple Brain Metastases
Name
med_013_04_045003.pdf
Description
Published version
Size
8.02 MB
Format
Adobe PDF
Checksum (MD5)
5313b388e67e1bff716cc4e28a171b6c
Author(s)
Cobi, Alban C.
Gray, Luke Alexander.
Mittmann, Elizabeth(Elizabeth R.)
Link, Steven B.
Hanumara, Nevan Clancy
Lyatskaya, Yulia
Roche, Ellen
Slocum, Alexander H
Zygmanski, Piotr
Date Issued
October 2019
Journal
Journal of Medical Devices
Publisher
ASME International
Citation
Cobi, Alban C. et al. "Design of a Reconfigurable Quality Assurance Phantom for Verifying the Spatial Accuracy of Radiosurgery Treatments." Journal of Medical Devices 13, 4 (October 2019): 045003 © 2019 ASME
Version
Final published version
Abstract
Radiation therapy frequently involves highly customized and complex treatments, employing sophisticated equipment, that require extensive patient-specific validation to verify the accuracy of the treatment plan as part of the clinical quality assurance (QA) process. This paper introduces a novel, reconfigurable QA phantom developed for the spatial validation of radiosurgery treatments of multiple brain metastases (MBM). This phantom works in conjunction with existing electronic portal imaging detector (EPID) technology to rapidly verify MBM treatment plans with submillimeter accuracy. The device provides a 12 × 12 × 12 cm³ active volume and multiple, independently configurable markers, in the form of 3 mm diameter radiopaque spheres, which serve as surrogates for brain lesions. The device is lightweight, portable, can be setup by a single operator, and is adaptable for use with external beam radiotherapy (EBRT) techniques and stereotactic linear accelerators (LINACs). This paper presents the device design and fabrication, along with initial testing and validation results both in the laboratory, using a coordinate measuring machine (CMM) and under simulated clinical conditions, using a radiosurgery treatment plan with 15 lesions. The device has been shown to place markers in space with a 0.45 mm root-mean-square error, which is satisfactory for initial clinical use. The device is undergoing further testing under simulated clinical conditions and improvements to reduce marker positional error.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
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DOI of Published Version
https://doi.org/10.1115/1.4044402
