MEMS-VCSEL swept-source optical coherence tomography for multi-MHz endoscopic structural and angiographic imaging
Name
1252064616-MIT.pdf
Size
3.89 MB
Format
Adobe PDF
Checksum (MD5)
633bae3c8ac653eb1f8e3c2e7c5349b2
Author(s)
Zhang, Jason,S.M.Massachusetts Institute of Technology.
Advisor(s)
James G. Fujimoto.
Alternative Title
Microelectromechanical-system, vertical-cavity surface-emitting laser swept-source optical coherence tomography for multi-MHz endoscopic structural and angiographic imaging
Date Issued
2021
Publisher
Massachusetts Institute of Technology
Abstract
Swept-source optical coherence tomography (SS-OCT) enables volumetric imaging of subsurface structure, but applications requiring wide fields of view, rapid imaging, and higher resolutions have been challenging because of the need for multi-MHz A-scan rates. Until now, achieving multi-MHz A-scan rates has been limited to Fourier-domain mode-locked lasers or stretched-pulse lasers. We describe a microelectromechanical-system, vertical-cavity surface-emitting laser (MEMS-VCSEL) for SS-OCT at A-scan rates of 2.4 and 3.0 MHz using a dual-channel acquisition system. Dual-channel operation enables simultaneous acquisition of Mach-Zehnder interferometer (MZI) fringes for sweep-to-sweep calibration and resampling, overcoming inherent optical clock limitations in state-of-the-art digitizers. We demonstrate structural OCT and OCT angiography (OCTA) imaging of the swine gastrointestinal tract using a suite of endoscopic devices, including a 3.2 mm diameter micromotor catheter, a 12 mm diameter tethered capsule, and a 12 mm diameter wide-field OCTA probe. MEMS-VCSELs promise to enable ultrahigh-speed SS-OCT with a scalable, low cost, and manufacturable technology, suitable for a diverse range of imaging applications.
Description
Thesis: S.M., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, February, 2021
Cataloged from the official PDF version of thesis.
Includes bibliographical references (pages 67-72).
Subjects
Electrical Engineering and Computer Science.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
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MIT theses may be protected by copyright. Please reuse MIT thesis content according to the MIT Libraries Permissions Policy, which is available through the URL provided.
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