Palladium-catalyzed coupling of functionalized primary and secondary amines with aryl and heteroaryl halides: two ligands suffice in most cases
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Buchwald_Palladium-Catalyzed Coupling.pdf
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Author(s)
Maiti, Debabrata
Fors, Brett P.
Henderson, Jaclyn L.
Nakamura, Yoshinori
Buchwald, Stephen Leffler
Date Issued
September 2010
Journal
Chemical Science
Publisher
Royal Society of Chemistry, The
Citation
Maiti, Debabrata, Brett P. Fors, Jaclyn L. Henderson, Yoshinori Nakamura, and Stephen L. Buchwald. “Palladium-Catalyzed Coupling of Functionalized Primary and Secondary Amines with Aryl and Heteroaryl Halides: Two Ligands Suffice in Most Cases.” Chemical Science 2, no. 1 (2011): 57.
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Author's final manuscript
Abstract
We report our studies on the use of two catalyst systems, based on the ligands BrettPhos and RuPhos, which provide the widest scope for Pd-catalyzed C–N cross-coupling reactions to date. Often low catalyst loadings and short reaction times can be used with functionalized aryl and heteroaryl coupling partners. The reactions are highly robust and can be set up and performed without the use of a glovebox. These catalysts should find wide application in the synthesis of complex molecules including pharmaceuticals, natural products and functional materials.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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DOI of Published Version
https://doi.org/10.1039/c0sc00330a
