Direct tablet formation by electrospinning and compaction
Name
933609980-MIT.pdf
Description
Full printable version
Size
11.1 MB
Format
Adobe PDF
Checksum (MD5)
ff71832a214f0e02608f4e1502db2877
Author(s)
Sondej, Nicholas Matti
Advisor(s)
Alexander H. Slocum.
Date Issued
2014
Publisher
Massachusetts Institute of Technology
Abstract
A process and physical system were developed to manufacture pharmaceutical tablets through an electrospinning operation and subsequent compaction. Theoretical simulations of the electrospinning were run to predict physical system performance, and a proof-of-concept device was designed, produced and tested. The process was demonstrated to be theoretically scalable to levels of production suitable for industrial pharmaceutical manufacturing. The system demonstrated clear advantages over preexisting pharmaceutical manufacturing equipment, eliminating airborne drug particulate matter, minimizing liquid drying time, and enabling a more agile, liquid-based continuous manufacturing process to be utilized for pharmaceutical production. Future work was specified to refine and optimize the process, and improve process control and monitoring in order to meet the pharmaceutical industry's strict regulatory controls.
Description
Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2014.
Cataloged from PDF version of thesis.
Includes bibliographical references (page 107).
Subjects
Mechanical Engineering.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
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