Metabolism in the Tumor Microenvironment
Name
annurev-cancerbio-030419-033333.pdf
Description
Published version
Size
3.71 MB
Format
Adobe PDF
Checksum (MD5)
22b88b4612f46036631e7ce03a34fceb
Author(s)
Lau, Allison N.
Vander Heiden, Matthew G.
Date Issued
March 9, 2020
Publisher
Annual Reviews
Citation
Lau, Allison N. and Vander Heiden, Matthew G. 2020. "Metabolism in the Tumor Microenvironment." 4 (1).
Version
Final published version
Abstract
Experiments in culture systems where one cell type is provided with abundant nutrients and oxygen have been used to inform much of our understanding of cancer metabolism. However, many differences have been observed between the metabolism of tumors and the metabolism of cancer cells grown in monoculture. These differences reflect, at least in part, the presence of nonmalignant cells in the tumor microenvironment and the interactions between those cells and cancer cells. However, less is known about how the metabolism of various tumor stromal cell types differs from that of cancer cells, and how this difference might inform therapeutic targeting of metabolic pathways. Emerging data have identified both cooperative and competitive relationships between different cell types in a tumor, and this review examines how four abundant stromal cell types in the tumor microenvironment, fibroblasts, T cells, macrophages, and endothelial cells, contribute to the metabolism of tumors.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1146/annurev-cancerbio-030419-033333
