Contribution of Untargeted Metabolomics for Future Assessment of Biotech Crops
Name
Contribution of Untargeted Metabolomics for Future Assessment of Biotech Crops_proof.pdf
Description
Accepted version
Size
564.17 KB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Christ, Bastien
Pluskal, Tomáš
Aubry, Sylvain
Weng, Jing-Ke
Date Issued
October 2018
Journal
Trends in Plant Science
Publisher
Elsevier BV
Citation
Bastien, Christ et al. "Contribution of Untargeted Metabolomics for Future Assessment of Biotech Crops." Trends in Plant Science 23, 12 (December 2018): P1047-1056 © 2018 Elsevier Ltd
Version
Author's final manuscript
Abstract
The nutritional value and safety of food crops are ultimately determined by their chemical composition. Recent developments in the field of metabolomics have made it possible to characterize the metabolic profile of crops in a comprehensive and high-throughput manner. Here, we propose that state-of-the-art untargeted metabolomics technology should be leveraged for safety assessment of new crop products. We suggest generally applicable experimental design principles that facilitate the efficient and rigorous identification of both intended and unintended metabolic alterations associated with a newly engineered trait. Our proposition could contribute to increased transparency of the safety assessment process for new biotech crops.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.tplants.2018.09.011
