Shape and Biomechanical Characteristics of Human Red Blood Cells in Health and Disease
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Author(s)
Diez Silva, Monica
Dao, Ming
Han, Jongyoon
Lim, Chwee Teck
Suresh, Subra
Date Issued
May 2010
Journal
MRS Bulletin
Publisher
Materials Research Society
Citation
Diez-Silva, Monica et al. “Shape and Biomechanical Characteristics of Human Red Blood Cells in Health and Disease.” MRS Bulletin 35.05 (2011) : 382-388. Copyright © Materials Research Society 2010
Version
Final published version
Abstract
The biconcave shape and corresponding deformability of the human red blood cell
(RBC) is an essential feature of its biological function. This feature of RBCs can be
critically affected by genetic or acquired pathological conditions. In this review, we
highlight new dynamic in vitro assays that explore various hereditary blood disorders
and parasitic infectious diseases that cause disruption of RBC morphology and
mechanics. In particular, recent advances in high-throughput microfluidic devices make
it possible to sort/identify healthy and pathological human RBCs with different
mechanobiological characteristics.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Department of Materials Science and Engineering
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1557/mrs2010.571
