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A framework for advancing our understanding of cancer-associated fibroblasts
Name
s41568-019-0238-1.pdf
Description
Published version
Size
1.35 MB
Format
Adobe PDF
Checksum (MD5)
5b5f53823e75867b9693a4c49af6f2e9
Author(s)
Sahai, Erik
Astsaturov, Igor
Cukierman, Edna
DeNardo, David G
Egeblad, Mikala
Evans, Ronald M
Fearon, Douglas
Greten, Florian R
Hingorani, Sunil R
Hunter, Tony
Date Issued
2020
Journal
Nature Reviews Cancer
Publisher
Springer Science and Business Media LLC
Version
Final published version
Abstract
© 2020, The Author(s). Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment with diverse functions, including matrix deposition and remodelling, extensive reciprocal signalling interactions with cancer cells and crosstalk with infiltrating leukocytes. As such, they are a potential target for optimizing therapeutic strategies against cancer. However, many challenges are present in ongoing attempts to modulate CAFs for therapeutic benefit. These include limitations in our understanding of the origin of CAFs and heterogeneity in CAF function, with it being desirable to retain some antitumorigenic functions. On the basis of a meeting of experts in the field of CAF biology, we summarize in this Consensus Statement our current knowledge and present a framework for advancing our understanding of this critical cell type within the tumour microenvironment.
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
10.1038/S41568-019-0238-1
