SH3PXD2A (SH3 and PX domains 2A)
Name
08-2015-SH3PXD2AID45995ch10q24.pdf
Size
360.36 KB
Format
Adobe PDF
Checksum (MD5)
4d32a31a54546ead7066b653ec860800
Author(s)
Li, Carman Man Chung
Jacks, Tyler E.
Date Issued
October 2017
Journal
Atlas of Genetics and Cytogenetics in Oncology and Haematology
Publisher
INIST-CNRS
Citation
Li, Carman Man-Chung and Tyler Jacks. “SH3PXD2A (SH3 and PX Domains 2A).” Atlas of Genetics and Cytogenetics in Oncology and Haematology 6 (2016): 326-330 © 2016 Atlas of Genetics and Cytogenetics in Oncology and Haematology
Version
Final published version
Abstract
The TKS5 protein, encoded by the gene SH3PXD2A, is a scaffolding protein essential for the formation of podosomes and invadopodia in untransformed cells and cancer cells, respectively. Podosomes and invadopodia (which collectively are termed invadosomes) are actin-rich cellular protrusions capable of secreting proteolytic enzymes that can degrade the extracellular matrix. These structures are thought to regulate cellular migration and invasion, as well as adhesion and the release of growth factors. In the context of cancer, TKS5-dependent invadopodia activity has been shown to play important roles in tumor growth and metastasis in various cancer types. Multiple isoforms of TKS5 exist due to alternative mRNA splicing and promoter usage.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-Noncommercial-No Derivative Works 2.0
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.4267/2042/62941
