Spatially and temporally controlled immune cell interactions using microscale tools
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Voldman_Spatially and.pdf
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388.85 KB
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305c1b3750ee19bb434c8f2995033f84
Author(s)
Dura, Burak
Voldman, Joel
Date Issued
June 2015
Journal
Current Opinion in Immunology
Publisher
Elsevier B.V.
Citation
Dura, Burak, and Joel Voldman. “Spatially and Temporally Controlled Immune Cell Interactions Using Microscale Tools.” Current Opinion in Immunology 35 (August 2015): 23–29.
Version
Author's final manuscript
Abstract
Many critical immunological responses are mediated by cell–cell interactions. Despite their capabilities, traditional techniques that rely on snapshot analysis or ensemble measurements can only provide a fragmentary picture of the complexity of these interactions. Emerging classes of new and versatile microscale tools hold great potential for enabling detailed investigation of these interactions with precise control in space and time, multiplexed measurement capability and high-throughput single-cell analysis. These features allow new ways of examining immune cell interactions that are not possible with traditional methods, improve the extent of information extracted from experiments, and reveal new findings. Here, we review recent developments in microscale tools that are paving the way for comprehensive analyses of cell–cell interactions in the immune system.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Microsystems Technology Laboratories
Massachusetts Institute of Technology. Research Laboratory of Electronics
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.coi.2015.05.006
