The Cancer Genome Atlas Pan-Cancer analysis project
Name
Lander_The cancer genome.pdf
Size
608.14 KB
Format
Adobe PDF
Checksum (MD5)
980c06c97e3eeeed34208d0122e3de5f
Author(s)
Park, Peter J.
Lander, Eric Steven
Date Issued
September 2013
Journal
Nature Genetics
Publisher
Nature Publishing Group
Citation
Chang, Kyle, Chad J Creighton, Caleb Davis, Lawrence Donehower, Jennifer Drummond, David Wheeler, Adrian Ally, et al. “The Cancer Genome Atlas Pan-Cancer analysis project.” Nature Genetics 45, no. 10 (September 26, 2013): 1113-1120.
Version
Final published version
Abstract
The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages. The Pan-Cancer initiative compares the first 12 tumor types profiled by TCGA. Analysis of the molecular aberrations and their functional roles across tumor types will teach us how to extend therapies effective in one cancer type to others with a similar genomic profile.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1038/ng.2764
