Enhancing cell therapies from the outside in: Cell surface engineering using synthetic nanomaterials
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Irvine_Enhancing cell.pdf
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1.99 MB
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Adobe PDF
Checksum (MD5)
35489fa85e2298462bd829bb21af7ff6
Author(s)
Stephan, Matthias T.
Irvine, Darrell J
Date Issued
May 2011
Journal
Nano Today
Publisher
Elsevier
Citation
Stephan, Matthias T., and Darrell J. Irvine. “Enhancing Cell Therapies from the Outside in: Cell Surface Engineering Using Synthetic Nanomaterials.” Nano Today 6, no. 3 (June 2011): 309–325.
Version
Author's final manuscript
Abstract
Therapeutic treatments based on the injection of living cells are in clinical use and preclinical development for diseases ranging from cancer to cardiovascular disease to diabetes. To enhance the function of therapeutic cells, a variety of chemical and materials science strategies are being developed that engineer the surface of therapeutic cells with new molecules, artificial receptors, and multifunctional nanomaterials, synthetically endowing donor cells with new properties and functions. These approaches offer a powerful complement to traditional genetic engineering strategies for enhancing the function of living cells.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Materials Science and Engineering
Ragon Institute of MGH, MIT and Harvard
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-Noncommercial-NoDerivatives
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.nantod.2011.04.001
