Development of novel polymeric nanoparticles with tailored architectures and functionalities/
Name
861621490-MIT.pdf
Description
Full printable version
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5.06 MB
Format
Adobe PDF
Checksum (MD5)
36b75d1f24e0200b9dab88d94ec396c2
Author(s)
Burts, Alan O. (Alan Omar)
Advisor(s)
Jeremiah A. Johnson.
Date Issued
2013
Publisher
Massachusetts Institute of Technology
Abstract
Developing a modular synthetic route to a combinatorial library of functional nanoparticles for applications like drug delivery is one of the main interests of our group. To this end, we have envisioned a novel nanoparticle architecture called a brush-arm star polymer (BASP), which has polymer brushes on the periphery shielding the core. Such nanoparticles were synthesized by, first, "graft-through" ring-opening metathesis polymerization (ROMP) of a norbornene-macromonomer to create the brush-arms, and second, cross-linking the arms with a bis-norbornene cross-linker to afford star polymers via the "arm-first" star polymer method. Functionality can be installed into the macromonomer (MM) or crosslinker preand post-polymerization. We took advantage of the highly efficient third-generation Grubbs catalyst to polymerize a polyethylene glycol (PEG) macromonomer (MM) and a bisnorbornene nitrobenzyloxycarbonyl (NBOC) photocleavable cross-linker to cross-link the brush-arms, which led to low-dispersity (Đ \=1.52) BASPs, while the more rigid RAFT initiator crosslinker led to low-dispersity (Đ
Description
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2013.
Cataloged from PDF version of thesis.
Includes bibliographical references (p. 41-47).
Subjects
Chemistry.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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