High-order chromatin architecture determines the landscape of chromosomal alterations in cancer
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Mirny_High-order.pdf
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81327fcce198bc7fa04a203bd331bd21
Author(s)
Fudenberg, Geoffrey
Getz, Gad
Meyerson, Matthew L.
Mirny, Leonid A.
Date Issued
November 2011
Journal
Nature Biotechnology
Publisher
Nature Publishing Group
Citation
Fudenberg, Geoff et al. “High Order Chromatin Architecture Shapes the Landscape of Chromosomal Alterations in Cancer.” Nature Biotechnology 29.12 (2011): 1109–1113.
Version
Author's final manuscript
Abstract
The accumulation of data on structural variation in cancer genomes provides an opportunity to better understand the mechanisms of genomic alterations and the forces of selection that act upon these alterations in cancer. Here we test evidence supporting the influence of two major forces, spatial chromosome structure and purifying (or negative) selection, on the landscape of somatic copy-number alterations (SCNAs) in cancer[superscript 1]. Using a maximum likelihood approach, we compare SCNA maps and three-dimensional genome architecture as determined by genome-wide chromosome conformation capture (HiC) and described by the proposed fractal-globule model[superscript 2, 3]. This analysis suggests that the distribution of chromosomal alterations in cancer is spatially related to three-dimensional genomic architecture and that purifying selection, as well as positive selection, influences SCNAs during somatic evolution of cancer cells.
Description
Author Manuscript 2012 June 01.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Physics
Massachusetts Institute of Technology. School of Engineering
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1038/nbt.2049
