Polarity and cell fate asymmetry in Caulobacter crescentus
Name
Laub_Polarity and cell.pdf
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1.01 MB
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Adobe PDF
Checksum (MD5)
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Author(s)
Tsokos, Christos G.
Laub, Michael T
Date Issued
November 2012
Journal
Current Opinion in Microbiology
Publisher
Elsevier
Citation
Tsokos, Christos G, and Michael T Laub. “Polarity and cell fate asymmetry in Caulobacter crescentus.” Current Opinion in Microbiology 15, no. 6 (December 2012): 744-750.
Version
Author's final manuscript
Abstract
The production of asymmetric daughter cells is a hallmark of metazoan development and critical to the life cycle of many microbes, including the α-proteobacterium Caulobacter crescentus. For Caulobacter, every cell division is asymmetric, yielding daughter cells with different morphologies and replicative potentials. This asymmetry in daughter cell fate is governed by the response regulator CtrA, a transcription factor that can also bind and silence the origin of replication. CtrA activity is controlled by a complex regulatory circuit that includes several polarly localized histidine kinases. This circuit ensures differential activation of CtrA in daughter cells, leading to their asymmetric replicative potentials. Here, we review progress in elucidating the molecular mechanisms regulating CtrA and the role of cellular polarity in this process.
MIT Department
Massachusetts Institute of Technology. Department of Biology
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1016/j.mib.2012.10.011
