Polymer-fiber-coupled field-effect sensors for label-free deep brain recordings
Name
journal.pone.0228076.pdf
Description
Published version
Size
2.17 MB
Format
Adobe PDF
Checksum (MD5)
63ef4d0d5197d21571b22bce4c1636f0
Author(s)
Canales, Andres
Jia, Xiaoting
Anikeeva, Polina
Date Issued
January 2020
Journal
PLoS ONE
Publisher
Public Library of Science (PLoS)
Citation
Guo, Yuanyuan et al. “Polymer-fiber-coupled field-effect sensors for label-free deep brain recordings.” PLoS ONE, 15, (January 2020): 0228076 © 2020 The Author(s)
Version
Final published version
Abstract
© 2020 Guo et al. network topography. On the other hand, optical imaging reveals the architecture of neural circuits, but relies on bulky optics and fluorescent reporters whose signals are attenuated by the brain tissue. Here we introduce implantable devices to record brain activities based on the field effect, which can be further extended with capability of label-free electrophysiological mapping. Such devices reply on light-addressable potentiometric sensors (LAPS) coupled to polymer fibers with integrated electrodes and optical waveguide bundles. The LAPS utilizes the field effect to convert electrophysiological activity into regional carrier redistribution, and the neural activity is read out in a spatially resolved manner as a photocurrent induced by a modulated light beam. Spatially resolved photocurrent recordings were achieved by illuminating different pixels within the fiber bundles. These devices were applied to record local field potentials in the mouse hippocampus. In conjunction with the raster-scanning via the single modulated beam, this technology may enable fast label-free imaging of neural activity in deep brain regions.
MIT Department
Massachusetts Institute of Technology. Research Laboratory of Electronics
Massachusetts Institute of Technology. Department of Materials Science and Engineering
McGovern Institute for Brain Research at MIT
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1371/JOURNAL.PONE.0228076
