Line-scanning Brillouin microscopy for rapid non-invasive mechanical imaging
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Line-scanning.pdf
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Author(s)
Zhang, Jitao
Fiore, Antonio
Kim, Hanyoup
Scarcelli, Giuliano
Yun, Seok Hyun (Andy)
Date Issued
October 2016
Journal
Scientific Reports
Publisher
Nature Publishing Group
Citation
Zhang, Jitao, Antonio Fiore, Seok-Hyun Yun, Hanyoup Kim, and Giuliano Scarcelli. “Line-Scanning Brillouin Microscopy for Rapid Non-Invasive Mechanical Imaging.” Scientific Reports 6, no. 1 (October 14, 2016).
Version
Final published version
Abstract
Brillouin spectroscopy probes the mechanical properties of material by measuring the optical frequency shift induced by photon-phonon scattering interactions. In traditional configurations, Brillouin spectrometers measure only one point of the sample at a time. This results in long acquisition times for mechanical imaging of large areas. In this work, we demonstrate a parallel detection configuration where the Brillouin shift of hundreds of points in a line can be measured simultaneously. In mm-sized samples, this novel configuration effectively shortens the acquisition time of two-dimensional Brillouin imaging from hours to tens of seconds, thus making it a powerful technology for label-free mechanical characterization of tissue and biomaterials.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Terms of Use
Creative Commons Attribution 4.0 International License
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DOI of Published Version
https://doi.org/10.1038/srep35398
