Recent discoveries and applications involving small-molecule microarrays
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nihms-545075.pdf
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1.79 MB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Hong, Jiyoung A
Neel, Dylan V
Wassaf, Dina
Caballero, Francisco
Koehler, Angela Nicole
Date Issued
November 2013
Journal
Current Opinion in Chemical Biology
Publisher
Elsevier BV
Citation
Hong, Jiyoung A., et al. “Recent Discoveries and Applications Involving Small-Molecule Microarrays.” Current Opinion in Chemical Biology, vol. 18, Feb. 2014, pp. 21–28.
Version
Author's final manuscript
Abstract
High-throughput and unbiased binding assays have proven useful in probe discovery for a myriad of biomolecules, including targets of unknown structure or function and historically challenging target classes. Over the past decade, a number of novel formats for executing large-scale binding assays have been developed and used successfully in probe discovery campaigns. Here we review the use of one such format, the small-molecule microarray (SMM), as a tool for discovering protein-small molecule interactions. This review will briefly highlight selected recent probe discoveries using SMMs as well as novel uses of SMMs in profiling applications. © 2013 Elsevier Ltd.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.CBPA.2013.09.020
