Chromatin Accessibility Impacts Transcriptional Reprogramming in Oocytes
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1-s2.0-S2211124718309409-main.pdf
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2.37 MB
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Checksum (MD5)
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Author(s)
Miyamoto, Kei
Allen, George E.
Jullien, Jerome
Otani, Tomoki
Bradshaw, Charles R.
Livesey, Frederick J.
Gurdon, John B.
Nguyen, Khoi Thien
Kumar, Dinesh
Kellis, Manolis
Date Issued
July 2018
Journal
Cell Reports
Publisher
Elsevier
Citation
Miyamoto, Kei et al. “Chromatin Accessibility Impacts Transcriptional Reprogramming in Oocytes.” Cell Reports 24, 2 (July 2018): 304–311
Version
Final published version
Abstract
Miyamoto et al. show genome-wide changes in chromatin accessibility during transcriptional reprogramming in oocytes using the frog nuclear transfer system. They demonstrate that donor cell chromatin states affect transcriptional reprogramming and changes in open chromatin during reprogramming are associated with specific transcription factors. Keywords:
open chromatin; transcriptional activation; reprogramming; nuclear transfer
MIT Department
Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
Creative Commons Attribution 4.0 International License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.celrep.2018.06.030
