Molecular fMRI
Name
Bartelle-2016-Molecular fMRI.pdf
Size
637.16 KB
Format
Adobe PDF
Checksum (MD5)
cf7657c17c8a5e6a75a41b328c9d9682
Author(s)
Barandov, Ali
Jasanoff, Alan Pradip
Bartelle, Benjamin B.
Date Issued
April 2016
Journal
Journal of Neuroscience
Publisher
Society for Neuroscience
Citation
Bartelle, B. B., A. Barandov, and A. Jasanoff. “Molecular fMRI.” Journal of Neuroscience 36.15 (2016): 4139–4148.
Version
Final published version
Abstract
Comprehensive analysis of brain function depends on understanding the dynamics of diverse neural signaling processes over large tissue volumes in intact animals and humans. Most existing approaches to measuring brain signaling suffer from limited tissue penetration, poor resolution, or lack of specificity for well-defined neural events. Here we discuss a new brain activity mapping method that overcomes some of these problems by combining MRI with contrast agents sensitive to neural signaling. The goal of this “molecular fMRI” approach is to permit noninvasive whole-brain neuroimaging with specificity and resolution approaching current optical neuroimaging methods. In this article, we describe the context and need for molecular fMRI as well as the state of the technology today. We explain how major types of MRI probes work and how they can be sensitized to neurobiological processes, such as neurotransmitter release, calcium signaling, and gene expression changes. We comment both on past work in the field and on challenges and promising avenues for future development.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Massachusetts Institute of Technology. Department of Nuclear Science and Engineering
Terms of Use
Creative Commons Attribution 4.0 International License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1523/jneurosci.4050-15.2016
