Low‐Cost, High‐Pressure‐Synthesized Oxygen‐Entrapping Materials to Improve Treatment of Solid Tumors
Name
Advanced Science - 2023 - Bi - Low‐Cost High‐Pressure‐Synthesized Oxygen‐Entrapping Materials to Improve Treatment of.pdf
Description
Published version
Size
3.96 MB
Format
Adobe PDF
Checksum (MD5)
10b16c79123e22fdd90e7eae3678ba4b
Author(s)
Bi, Jianling
Witt, Emily
Voltarelli, Vanessa A.
Feig, Vivian R.
Venkatachalam, Veena
Boyce, Hannah
McGovern, Megan
Gutierrez, Wade R.
Rytlewski, Jeffrey D.
Bowman, Kate R.
Date Issued
February 2, 2023
Journal
Advanced Science
Publisher
Wiley
Citation
J. Bi, E. Witt, V. A. Voltarelli, V. R. Feig, V. Venkatachalam, H. Boyce, M. McGovern, W. R. Gutierrez, J. D. Rytlewski, K. R. Bowman, A. C. Rhodes, A. N. Cook, B. N. Muller, M. G. Smith, A. R. Ramos, H. Panchal, R. D. Dodd, M. D. Henry, A. Mailloux, G. Traverso, L. E. Otterbein, J. D. Byrne, Low-Cost, High-Pressure-Synthesized Oxygen-Entrapping Materials to Improve Treatment of Solid Tumors. Adv. Sci. 2023, 10, 2205995.
Version
Final published version
Abstract
Tumor hypoxia drives resistance to many cancer therapies, including radiotherapy and chemotherapy. Methods that increase tumor oxygen pressures, such as hyperbaric oxygen therapy and microbubble infusion, are utilized to improve the responses to current standard‐of‐care therapies. However, key obstacles remain, in particular delivery of oxygen at the appropriate dose and with optimal pharmacokinetics. Toward overcoming these hurdles, gas‐entrapping materials (GeMs) that are capable of tunable oxygen release are formulated. It is shown that injection or implantation of these materials into tumors can mitigate tumor hypoxia by delivering oxygen locally and that these GeMs enhance responsiveness to radiation and chemotherapy in multiple tumor types. This paper also demonstrates, by comparing an oxygen (O2)‐GeM to a sham GeM, that the former generates an antitumorigenic and immunogenic tumor microenvironment in malignant peripheral nerve sheath tumors. Collectively the results indicate that the use of O2‐GeMs is promising as an adjunctive strategy for the treatment of solid tumors.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
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DOI of Published Version
https://doi.org/10.1002/advs.202205995
