Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions
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acs.chemrev.6b00512.pdf
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23.54 MB
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Adobe PDF
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Author(s)
Ruiz-Castillo, Paula
Buchwald, Stephen Leffler
Date Issued
September 2016
Journal
Chemical Reviews
Publisher
American Chemical Society (ACS)
Citation
Ruiz-Castillo, Paula and Buchwald, Stephen L. “Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions.” Chemical Reviews 116, 19 (September 2016): 12564–12649 © 2016 American Chemical Society
Version
Final published version
Abstract
Pd-catalyzed cross-coupling reactions that form C-N bonds have become useful methods to synthesize anilines and aniline derivatives, an important class of compounds throughout chemical research. A key factor in the widespread adoption of these methods has been the continued development of reliable and versatile catalysts that function under operationally simple, user-friendly conditions. This review provides an overview of Pd-catalyzed N-arylation reactions found in both basic and applied chemical research from 2008 to the present. Selected examples of C-N cross-coupling reactions between nine classes of nitrogen-based coupling partners and (pseudo)aryl halides are described for the synthesis of heterocycles, medicinally relevant compounds, natural products, organic materials, and catalysts.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/ACS.CHEMREV.6B00512
