Nuclear Mechanopathology and Cancer Diagnosis
Name
Uhler-Shiva-TIC-final.pdf
Size
1.35 MB
Format
Adobe PDF
Checksum (MD5)
2b9ae7385c171d4f97ed9e1d565b8652
Author(s)
Uhler, Caroline
Shivashankar, G.V.
Date Issued
April 2018
Journal
Trends in Cancer
Publisher
Elsevier BV
Citation
Uhler, Caroline and G.V. Shivashankar. "Nuclear Mechanopathology and Cancer Diagnosis." Trends in Cancer 4, 4 (April 2018): P320-331.
Version
Author's final manuscript
Abstract
Abnormalities in nuclear and chromatin organization are hallmarks of many diseases including cancer. This review provides our understanding of how the cellular microenvironment regulates nuclear morphology and with it the spatial organization of chromosomes and genes, resulting in cell-type specific genomic programs. We also discuss the molecular basis for maintaining nuclear and genomic integrity and how alterations in nuclear mechanotransduction pathways result in various diseases. Finally, we highlight the importance of digital pathology based on nuclear morphometric features combined with single-cell genomics for early cancer diagnostics.
MIT Department
Massachusetts Institute of Technology. Laboratory for Information and Decision Systems
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Institute for Data, Systems, and Society
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.trecan.2018.02.009
