Biogenetically-Inspired Total Synthesis of Epidithiodiketopiperazines and Related Alkaloids
Name
Kim-2015-Biogenetically-inspired.pdf
Size
4.63 MB
Format
Adobe PDF
Checksum (MD5)
8406e1d9cdcf7fa4d001ceb446bb1b32
Author(s)
Kim, Justin
Movassaghi, Mohammad
Date Issued
April 2015
Journal
Accounts of Chemical Research
Publisher
American Chemical Society (ACS)
Citation
Kim, Justin, and Mohammad Movassaghi. “Biogenetically-Inspired Total Synthesis of Epidithiodiketopiperazines and Related Alkaloids.” Accounts of Chemical Research 48, no. 4 (April 21, 2015): 1159–1171. © 2015 American Chemical Society
Version
Final published version
Abstract
Natural products chemistry has historically been the prime arena for the discovery of new chemical transformations and the fountain of insights into key biological processes. It remains a fervent incubator of progress in the fields of chemistry and biology and an exchange mediating the flow of ideas between these allied fields of science. It is with this ethos that our group has taken an interest in and pursued the synthesis of a complex family of natural products termed the dimeric epipolythiodiketopiperazine (ETP) alkaloids. We present here an Account of the highly complex target molecules to which we pegged our ambitions, our systematic and relentless efforts toward those goals, the chemistry we developed in their pursuit, and the insight we have gained for their translational potential as potent anticancer molecules.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1021/ar500454v
