Cytosolic Uptake of Large Monofunctionalized Dextrans
Name
nihms971102.pdf
Description
Accepted version
Size
700.3 KB
Format
Adobe PDF
Checksum (MD5)
09604e27be583816f44cb4dd00afb0a3
Author(s)
Chyan, Wen
Kilgore, Henry R.
Raines, Ronald T
Date Issued
April 2018
Journal
Bioconjugate Chemistry
Publisher
American Chemical Society (ACS)
Citation
Cyan, Wen et al. "Cytosolic Uptake of Large Monofunctionalized Dextrans." Bioconjugate Chemistry 29, 6 (April 2018): 1942-1949 © 2018 American Chemical Society
Version
Author's final manuscript
Abstract
Dextrans are a versatile class of polysaccharides with applications that span medicine, cell biology, food science, and consumer goods. Here, we report on a new type of large monofunctionalized dextran that exhibits unusual properties: efficient cytosolic and nuclear uptake. This dextran permeates various human cell types without the use of transfection agents, electroporation, or membrane perturbation. Cellular uptake occurs primarily through active transport via receptor-mediated processes. These monofunctionalized dextrans could serve as intracellular delivery platforms for drugs or other cargos. Keywords: carbohydrates; fluorescence; endocytosis; probes; conjugate acid-base pairs
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/acs.bioconjchem.8b00198
