Trade-offs between retroactivity and noise in connected transcriptional components
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Del Vecchio_Trade-offs between.pdf
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Author(s)
Del Vecchio, Domitilla
Herath, Narmada K.
Date Issued
June 2014
Journal
Proceedings of the 2014 American Control Conference
Citation
Herath, Narmada, and Domitilla Del Vecchio. “Trade-Offs Between Retroactivity and Noise in Connected Transcriptional Components.” 2014 American Control Conference (June 2014).
Version
Author's final manuscript
Abstract
At the interconnection of two gene transcriptional components in a biomolecular network, the noise in the downstream component can be reduced by increasing its gene copy number. However, this method of reducing noise increases the load applied to the upstream system, called retroactivity, thereby causing a perturbation in the upstream system. In this work, we quantify the error in the system trajectories caused by perturbations due to retroactivity and noise, and analyze the trade-off between these two perturbations. We model the system as a set of nonlinear chemical Langevin equations and quantify the trade-off by employing contraction theory for stochastic systems.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Department of Mechanical Engineering
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1109/ACC.2014.6859174
