Scaling single-cell genomics from phenomenology to mechanism
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Author(s)
Tanay, Amos
Regev, Aviv
Date Issued
January 2017
Journal
Nature
Publisher
Nature Publishing Group
Citation
Tanay, Amos and Aviv Regev. “Scaling Single-Cell Genomics from Phenomenology to Mechanism.” Nature 541, 7637 (January 2017): 331–338 © 2017 Macmillan Publishers Limited, part of Springer Nature
Version
Author's final manuscript
Abstract
Three of the most fundamental questions in biology are how individual cells differentiate to form tissues, how tissues function in a coordinated and flexible fashion and which gene regulatory mechanisms support these processes. Single-cell genomics is opening up new ways to tackle these questions by combining the comprehensive nature of genomics with the microscopic resolution that is required to describe complex multicellular systems. Initial single-cell genomic studies provided a remarkably rich phenomenology of heterogeneous cellular states, but transforming observational studies into models of dynamics and causal mechanisms in tissues poses fresh challenges and requires stronger integration of theoretical, computational and experimental frameworks.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1038/NATURE21350
